Evidence map›Paper›PMID 42444491›Full record

ArticleGut microbes2026

Distinct trajectories of urbanization shape the human gut microbiome across South Asia.

Shreya L Ramachandran, Nagarjuna Pasupuleti, Richard J Abdill, Gamini Adikari, Bhavna Ahlawat, Ran Blekhman, Victoria Burgo, Emily R Davenport, Aparna Dwivedi, Shristee Gupta and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Shreya L RamachandranDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6760-5053
Nagarjuna PasupuletiAncient DNA Laboratory, Birbal Sahni Institute of Palaeosciences, Lucknow, India.ORCID 0000-0002-1886-4400
Richard J AbdillSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-9565-5832
Gamini AdikariThe Postgraduate Institute of Archaeology (PGIAR), University of Kelaniya, Colombo, Sri Lanka.
Bhavna AhlawatAncient DNA Laboratory, Birbal Sahni Institute of Palaeosciences, Lucknow, India.
Ran BlekhmanSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-3218-613X
Victoria BurgoDuchossois Family Institute, University of Chicago, Chicago, IL, USA.
Emily R DavenportDepartment of Biology, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-6938-4933
Aparna DwivediAncient DNA Laboratory, Birbal Sahni Institute of Palaeosciences, Lucknow, India.
Shristee GuptaAncient DNA Laboratory, Birbal Sahni Institute of Palaeosciences, Lucknow, India.
Thadiyan Parambil IjinuNaturae Scientific, Kerala University-Business Innovation and Incubation Centre, Thiruvananthapuram, India.ORCID 0000-0002-0228-8904
Tiatoshi JamirDepartment of History & Archaeology, Nagaland University, Meriema, India.
Roheet KaruVARASA- Association of Cultural Heritage and Archaeology, Pune, India.
Amit KaushikDepartment of Agricultural Biotechnology, College of Biotechnology, Chaudhary Charan Singh Haryana Agricultural University, Hisar, India.
John Milton KomarabathiniDepartment of History, Government Degree College, Bhadrachalam, India.
LaithangpuiiDepartment of History, ICFAI University, Aizawl, India.
Joseph LalzarlianaDepartment of History and Ethnography, Mizoram University, Aizawl, India.
Tsering NorbuRock Art and Historical Society of Spiti, Kaza, India.
Tlana PautuIndependent Researcher Affiliated With SEL Foundation, Aizawl, India.
Kantikumar PawarVARASA- Association of Cultural Heritage and Archaeology, Pune, India.
Arjun S RamanDuchossois Family Institute, University of Chicago, Chicago, IL, USA.
Ramanujam RamaswamyDuchossois Family Institute, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7448-6574
Ruwandi RanasingheInstitute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka.
RashmiAncient DNA Laboratory, Birbal Sahni Institute of Palaeosciences, Lucknow, India.
Sreejith Pongillyathundi SasidharanThe National Society of Ethnopharmacology, Thiruvananthapuram, India.ORCID 0000-0002-8840-2754
Tharigopula SatheeshDepartment of Research, Vivekananda Memorial Hospital, Swami Vivekananda Youth Movement, Mysuru, India.
Shalini ShajiDepartment of Anthropology, University of Hyderabad, Gachibowli, India.
Jason W ShapiroCenter for Research Informatics, University of Chicago, Chicago, IL, USA.
Ekta SinghDepartment of Earth Sciences, Indian Institute of Technology, Roorkee, India.
Vanlalhuma SingsonArt and Culture Department, Government of Mizoram, Aizawl, India.
Anitha SundararajanDuchossois Family Institute, University of Chicago, Chicago, IL, USA.
Tennekoon Kamani HInstitute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka.
David TetsoDepartment of Anthropology, Kohima Science College, Kohima, India.
Jose A Urban AragonDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Anjana H J WelikalaInstitute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka.
Ruokuonuo Rose YhomeThe Highland Institute, Kohima, India.
Niraj RaiAncient DNA Laboratory, Birbal Sahni Institute of Palaeosciences, Lucknow, India.
Maanasa RaghavanDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.

Funding

Reconstructing the evolutionary history of humans and human-associated microbes in South Asia using an integrated genomics approachR35GM143094 · NIGMS · UNIVERSITY OF CHICAGO · PI RAGHAVAN, MAANASA · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM143094
6 · The paper itself

Abstract

Human gut microbiomes respond to lifestyle transitions, yet the extent to which these responses are conserved across spatio-cultural contexts remains undercharacterized. We present the South Asian MicroBiome ARray (SAMBAR), a population-scale 16S gut microbiome study of 575 adults from ten geographically and socio-culturally diverse South Asian communities. Each community was sampled in ancestral villages and urban centers, enabling controlled comparisons of geography and lifestyle. Relative to global cohorts, SAMBAR microbiomes occupy a distinct compositional space with stronger correlation to geography and community membership than lifestyle. Microbiome responses to lifestyle transitions are largely community-driven, including the acquisition of wheat- and dairying-associated microbial modules in some communities that may facilitate non-genetic adaptation to lactase nonpersistence. Concurrently, we identify significant associations of urbanization markers with increased abundance of disease-linked taxa, especially

Indexed as

BacteriaGastrointestinal MicrobiomeUrbanizationAdultAsia, SouthernFecesFemaleHumansLife StyleMaleMiddle AgedRNA, Ribosomal, 16SSouth Asian PeopleRNA, Ribosomal, 16SGut microbiomelifestyle transitionmetabolic diseaseSouth Asiaurbanization

Identifiers

PMID42444491
PMCPMC13371495

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.