ArticleFrontiers in neurology
Association of the hemoglobin glycation index with the large-artery atherosclerosis subtype in ischemic stroke: a dual-cohort study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The hemoglobin glycation index (HGI) reflects discordance between measured HbA1c and glucose-predicted HbA1c, but in acute ischemic stroke (IS) it may also capture stress-hyperglycemia-related fasting plasma glucose (FPG) elevation. We examined the association of HGI with large-artery atherosclerosis (LAA) and in-hospital mortality. Methods: We retrospectively analyzed 4,500 IS patients from MIMIC-IV and 330 patients from an external clinical cohort. HGI was calculated using cohort-specific FPG-HbA1c regression equations. Multivariable logistic regression and restricted cubic spline analyses assessed associations with LAA and mortality. Boruta feature selection, exploratory Mendelian randomization (MR), and Results: Lower HGI was independently associated with higher LAA risk in both cohorts (MIMIC-IV: OR = 0.579, Conclusion: Low HGI was associated with higher LAA risk and in-hospital mortality in IS. This signal overlaps with stress-hyperglycemia-related FPG-HbA1c discordance; therefore, HGI may be useful for risk stratification but should not be interpreted as an independent causal glycation phenotype.
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