ArticleRSC advances2026
Development of PHB-based bio-nanocomposite films with enhanced bioactivity and cytocompatibility for alveolar bone regeneration.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar bone regeneration remains a significant challenge in dentistry and maxillofacial surgery due to the limited availability of autografts and the complexity of restoring the native bone microenvironment. In the present study, multifunctional bio-nanocomposite films composed of polyhydroxybutyrate (PHB), LAPONITE® nanoclay (LAP), and guar gum (GG) were fabricated by the solvent-casting technique and investigated as potential bioresorbable films for alveolar bone regeneration. Structural and physiological characteristics, characterized using FESEM, EDX, FTIR, XRD, and TGA confirmed the successful incorporation of LAPONITE® within the PHB/GG matrix and revealed significant modifications in the morphology, crystallinity, thermal behaviour, and surface characteristics of the films. The incorporation of LAPONITE® increased film thickness from 0.056 ± 0.005 mm in the control to 0.156 ± 0.007 mm in 10 wt% and significantly influenced the mechanical performance and porous microstructure of the bio-nanocomposites. Among the investigated formulations, the 5 wt% bio-nanocomposite film exhibited the most balanced combination of porous morphology, mechanical strength (123.90 ± 4.25 MPa), biomineralization behaviour, controlled degradation profile, antimicrobial activity, and cytocompatibility.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.