Evidence map›Paper›PMID 42444821›Full record

ReviewFrontiers in oncology2026

Metabolomics-based exploration of the pathogenesis of breast cancer-related fatigue and progress of traditional Chinese medicine intervention.

Yidi Jiang, Chaofan Zhao, Qi Qiu, Qin Feng, Le Yang, Zhengcan Zhou, Mingqian Jia, Huiru Liao, Qinnan Li, Ye Sun and 4 more

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yidi Jiang *State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Chaofan Zhao *State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Qi Qiu *State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Qin FengShandong Key Laboratory of Gelatin-Based Drug Research and Development, National Engineering Technology Research Center for Gelatin-based TCM, Shandong Provincial Engineering Research Center of Gelatin-Based Traditional Chinese Medicine for Technology Innovation and Application, Dong'e Ejiao Co., Ltd., Liaocheng, China.
Le YangState Key Laboratory of Dampness Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhengcan ZhouShandong Key Laboratory of Gelatin-Based Drug Research and Development, National Engineering Technology Research Center for Gelatin-based TCM, Shandong Provincial Engineering Research Center of Gelatin-Based Traditional Chinese Medicine for Technology Innovation and Application, Dong'e Ejiao Co., Ltd., Liaocheng, China.
Mingqian JiaShandong Key Laboratory of Gelatin-Based Drug Research and Development, National Engineering Technology Research Center for Gelatin-based TCM, Shandong Provincial Engineering Research Center of Gelatin-Based Traditional Chinese Medicine for Technology Innovation and Application, Dong'e Ejiao Co., Ltd., Liaocheng, China.
Huiru LiaoState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Qinnan LiState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Ye SunState Key Laboratory of Dampness Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Jianjun GuShandong Key Laboratory of Gelatin-Based Drug Research and Development, National Engineering Technology Research Center for Gelatin-based TCM, Shandong Provincial Engineering Research Center of Gelatin-Based Traditional Chinese Medicine for Technology Innovation and Application, Dong'e Ejiao Co., Ltd., Liaocheng, China.
Bo YangState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Ning ZhangState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.
Hui SunState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer-related fatigue is a persistent and subjective sense of tiredness caused by either the cancer itself or its treatments. This fatigue is disproportionate to recent physical activity and significantly interferes with daily life. The exact pathogenesis of Breast cancer-related fatigue remains unclear. Breast cancer cells induce metabolic abnormalities through reprogramming. This disruption in metabolic balance-particularly in various systems-may contribute to Breast cancer-related fatigue by compromising the body's overall metabolic homeostasis, all while supporting the biosynthetic demands of cancer cell proliferation. Current pharmacological treatments for cancer-related fatigue have demonstrated limited and inconsistent efficacy. These treatments are often hindered by a narrow drug target profile, high rates of adverse effects, and the complex mechanisms underlying fatigue, particularly those related to metabolic changes. Traditional Chinese medicine, with its multi-target modulation and lower toxicity, holds significant potential as long-term adjunctive or alternative treatments for Breast cancer-related fatigue. This article reviews the current understanding of the metabolic causes of Breast cancer-related fatigue and explores the role of traditional Chinese medicine interventions, offering new insights into potential targeted therapies for this condition.

Indexed as

breast cancercancer-related fatigueherbmetabolomicstraditional Chinese medicine

Identifiers

PMID42444821
PMCPMC13357231

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.