Evidence map›Paper›PMID 42444855›Full record

ArticleJournal of thoracic disease2026

Silencing of BCAT1 induces ferroptosis and inhibits brain metastasis of non-small cell lung cancer via activating the cGAS-STING pathway.

Fan Yang, Yuying Li, Huijiao Zhou, Xin Bi, Dongjie Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan Yang *Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yuying Li *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Huijiao ZhouDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xin BiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Dongjie WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Brain metastasis (BM) in non-small cell lung cancer (NSCLC) is associated with the reprogramming of branched-chain amino acid (BCAA) metabolism. This investigation sought to comprehend the function and molecular process of BCAT1 during the BM associated with NSCLC. Methods: BCAT1 expression was assessed in NSCLC brain metastases (NSCLC-BM) tissues and NSCLC cell lines using quantitative real-time PCR and western blotting. Results: BCAT1 expression was elevated in NSCLC-BM tissues and cells. Knocking down BCAT1 inhibited cell viability, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness, disrupted BCAA metabolic reprogramming, and promoted ferroptosis Conclusions: In conclusion, BCAT1 promotes NSCLC-BM by modulating BCAA metabolic reprogramming through suppressing the cGAS-STING pathway, highlighting the potential of BCAT1 to be targeted in therapy.

Indexed as

BCAT1brain metastasis (BM)branched-chain amino acid metabolism (BCAA metabolism)Non-small cell lung cancer (NSCLC)the cGAS-STING pathway

Identifiers

PMID42444855
PMCPMC13358789

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.