ArticleJournal of thoracic disease2026
Identification of neutrophil extracellular traps-related genes as feature genes and potential therapeutic targets in pulmonary hypertension.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neutrophil extracellular traps (NETs) might be promising targets for the evaluation and treatment of pulmonary hypertension. However, no study has systematically screened NETs as feature genes and therapeutic targets in pulmonary hypertension. The present study aims precisely to address this issue. Methods: GSE15197, GSE48149 and GSE53408 were used as the training group, whereas GSE113439 was used as the validation group for comprehensive bioinformatics analyses, and the screened feature genes were further confirmed using immunoblotting with animal lung tissues. Results: First, 12 differentially expressed NETs-related genes were significantly upregulated in pulmonary hypertension patients compared with healthy controls. Second, immune infiltration analysis revealed that immature B cells, immature dendritic cells, T helper cells and memory CD8+ T cells were increased in pulmonary hypertension patients. Third, three machine learning models identified five feature genes for pulmonary hypertension, including Conclusions: Five NETs-related genes, namely
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.