ArticleFrontiers in medicine2026
Hypophosphatemia-factors associated with its development and 90-day mortality effect: a prospective observational study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
Background: Several factors are associated with hypophosphatemia. There is a paucity of data regarding the effects of restrictive energy delivery and phosphate renal handling with hypophosphatemia in the critically ill patient. Methods: This is a single-center observational study. Patients were included if they were admitted ventilated and their ICU stay was at least 48 h. Baseline characteristics were recorded upon admission; other variables were collected daily during the first five admission days: SOFA1 score, serum phosphate, energy delivery, phosphate delivery and fluid balance. A 6-h urine collection for phosphate and creatinine was performed daily. Creatinine clearance (CrCl Results: One hundred eighty-one patients were included in the analysis. One hundred and nine (60.22%) developed hypophosphatemia. They were younger, had lower APACHE2 score, and were admitted more frequently due to trauma. No association of energy delivery with hypophosphatemia was found. In a multivariate analysis only log of CrCl Conclusion: Creatinine clearance based on a 6-h urine collection and TmP/GFR were associated with hypophosphatemia, whereas energy delivery was not. Age and APACHE2 were associated with 90-d mortality, but hypophosphatemia was not.
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