ArticleFrontiers in immunology2026
Immunological and clinical characteristics of severe thrombocytopenia in neonates with Kasabach-Merritt phenomenon.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to characterize the immune profile of neonates with Kasabach-Merritt phenomenon (KMP) and to identify clinical features linked to severe thrombocytopenia in these patients. Methods: This multicenter retrospective study included neonates diagnosed with KMP based on established criteria. The peripheral blood lymphocyte subsets, complement levels, and humoral immunity were compared between KMP neonates and controls. KMP neonates were further divided into severe and non-severe groups based on whether the platelet count was <20 × 10 Results: A total of 32 KMP neonates were included (13 in the severe group and 19 in the non-severe group). Compared with controls, KMP neonates had reduced CD3 Conclusion: Neonates with KMP showed immunological abnormalities, including decreases in helper T cells and B cells. Prolonged APTT and elevated ferritin were identified as independent risk factors for severe thrombocytopenia in KMP.
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