ReviewFrontiers in bioengineering and biotechnology2026
Harnessing piezoelectricity for bone tissue engineering: recapitulating the electrophysiological microenvironment through smart biomaterials.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Natural bone tissue is a highly dynamic electrophysiological microenvironment, where endogenous piezoelectricity plays a pivotal role in regulating bone remodeling and homeostasis. Addressing the complex clinical challenges of bone defects, piezoelectric biomaterials have emerged as a revolutionary self-powered therapeutic strategy, reconstructing this critical biophysical niche through electromechanical conversion. This article systematically reviews the classification and characteristics of inorganic ceramics, organic polymers, composites, and emerging systems. Advanced energy conversion strategies, ranging from physiological motion to low-intensity pulsed ultrasound actuation, are critically evaluated. Furthermore, the multi-scale mechanisms involving ion channel activation, cellular energy metabolism reprogramming, osteoimmune microenvironment remodeling, and osteogenic gene transcription and mineralization are elaborated. Ultimately, this review aims to provide profound theoretical guidance for the clinical translation of next-generation smart orthopedic implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.