Evidence map›Paper›PMID 42445407›Full record

ArticleTranslational cancer research2026

Tumor-derived CCL20 activates tumor-associated neutrophils, predicting good prognosis in endometrial cancer.

Linyan Zhu, Wenwu Luo, Siyu Li, Chengkang Wu, Zhi Wang, Qiang Wu, Keshuo Ding

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Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Linyan Zhu *Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Wenwu Luo *Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Siyu LiDepartment of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Chengkang WuDepartment of Clinical Medicine, The First Clinical College, Anhui Medical University, Hefei, China.
Zhi WangDepartment of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Qiang WuDepartment of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Keshuo DingDepartment of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endometrial cancer (EC) is the sixth most common cancer in women. A rising age-standardized incidence rate of EC has been observed globally. Tumor-associated neutrophils (TANs) have been demonstrated to be a "double-edged sword" in human cancers. We aimed to study the role of CCL20 and neutrophil infiltration in human EC in the study. Methods: Differential expression genes (DEGs) associated with chemokines in EC compared with normal samples were analyzed based on The Cancer Genome Atlas (TCGA)-Uterine Corpus Endometrial Carcinoma (UCEC) database, and DEGs associated with neutrophil infiltration were screened out as candidate genes. Through clinical samples, we verified the expression of Results: Conclusions: CCL20 is an important biomarker in human EC, which is highly expressed and is strongly correlated with neutrophil infiltration in EC. Moreover, high level of CCL20 and neutrophil infiltration are associated with favorable prognosis in patients with EC. Our findings suggest that CCL20 could be potentially used for prognostic prediction and treatment in human EC.

Indexed as

CCL20endometrial cancer (EC)immune microenvironmentTumor-associated neutrophils (TANs)

Identifiers

PMID42445407
PMCPMC13357334

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.