CNTN-1 regulates malignant biological behaviors of lung squamous cell carcinoma (LUSC) via the endoplasmic reticulum stress (ERS)/epithelial-mesenchymal transition (EMT) axis.

Kaimei Zhou, Weijie Dong, Shengjin Li, Depeng Jiang, Qi Wu, Zimo Wang, Minchao Li, Ruijie Zhang

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Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Kaimei ZhouDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Weijie DongDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Shengjin LiDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Depeng JiangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Qi WuDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Zimo WangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Minchao LiDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Ruijie ZhangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung squamous cell carcinoma (LUSC) is characterized by high malignancy, strong invasive and metastatic potential, and poor overall prognosis, and the core molecular mechanisms underlying its malignant progression remain to be further elucidated. This study aimed to investigate the effects of Contactin-1 (CNTN-1) on the malignant biological behaviors of tumor cells and its underlying molecular mechanisms in LUSC. Methods: A Results: A total of 5,961 DEGs were identified by transcriptome sequencing, which were mainly enriched in cellular immune response, cytokine-cytokine receptor interaction, phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and other signaling pathways. Conclusions:

Indexed as

Contactin-1 (CNTN-1)endoplasmic reticulum stress (ERS)epithelial-mesenchymal transition (EMT)lung squamous cell carcinoma (LUSC)phosphatidylinositol 3-kinase-protein kinase B signaling pathway (PI3K-Akt signaling pathway)

Identifiers

PMID42445425

DOI10.21037/tcr-2026-0697

PMCPMC13357337

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.