Evidence map›Paper›PMID 42445429›Full record

ArticleTranslational cancer research2026

METTL16-mediated upregulation of LINC00665 inhibits the apoptosis of breast cancer via regulating miR-28-5p/GLG1 axis.

Ya Zhou, Jie Ren, Xiaojuan Cai, Shiyu Lu, Hanbing Gu, Weizhe Xu, Xun Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ya Zhou *Thyroid and Breast Surgery Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jie Ren *Thyroid and Breast Surgery Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xiaojuan CaiThyroid and Breast Surgery Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Shiyu LuThyroid and Breast Surgery Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Hanbing GuThyroid and Breast Surgery Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Weizhe XuThyroid and Breast Surgery Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xun ZhuThyroid and Breast Surgery Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Long non-coding RNAs (lncRNAs) are intensively involved in the progression of breast cancer. This study aimed to investigate the potential of LINC00665 in breast cancer. Methods: RNA expression was determined by quantitative reverse transcriptase polymerase chain reaction. The binding sites between miR-28-5p and LINC00665/golgi glycoprotein 1 (GLG1) was predicted by Starbase3. The bindings sites were confirmed by luciferase assay. N6-methyladenosine (m6A) modification of LINC00665 was determined by methylated RNA immunoprecipitation assay. Cell viability was determined by Cell Counting Kit-8 assay. Cell migration was detected by wound healing assay. Cell invasion was detected by transwell assay. Cell apoptosis was detected using flow cytometry. Results: We found that methyltransferase-like 16 (METTL16)-mediated m6A modification drove the upregulation of LINC00665 in breast cancer. However, LINC00665 knockdown inhibited the proliferation, migration and invasion of breast cancer cells, as well as promoted cell apoptosis. Furthermore, LINC00665 sponged miR-28-5p to upregulate GLG1. GLG1 overexpression alleviated the effects of LINC00665 knockdown and mediated malignant behaviors of breast cancer cells. Conclusions: Taken together, LINC00665 promotes the progression of breast cancer via regulating miR-28-5p/GLG1 axis.

Indexed as

apoptosisBreast cancerLINC00665metastasis

Identifiers

PMID42445429
PMCPMC13357086

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.