SynthesisFrontiers in allergy2026
Effects of vitamin D levels and vitamin D supplementation on allergic diseases: an umbrella review.
Synthesis in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association between vitamin D levels/supplementation and the risk of allergic diseases has been extensively studied. However, the strength and consistency of the existing evidence remain unclear, and most reviews have focused on single diseases. This umbrella review aims to systematically evaluate the current meta-analytic evidence on the associations between vitamin D and allergic diseases, in order to establish a hierarchy of evidence and identify research gaps. Methods: PubMed, Embase, Cochrane Library, and Web of Science were systematically searched from inception to October 21, 2025. Summary effect estimates, 95% confidence intervals, I Results: A total of 14 eligible articles were included, yielding 16 associations (total population: 66,387). The credibility of evidence assessment revealed the following: the association between serum 25(OH)D levels and urticaria was graded as highly suggestive evidence (MD -9.35, -12.27 to -6.44, class II); the associations between serum 25(OH)D levels and allergic rhinitis and between vitamin D supplementation and urticaria were graded as suggestive evidence (SMD -1.29, -1.92 to -0.65, class III). Vitamin D supplementation significantly alleviated symptoms in allergic rhinitis (SMD -2.25, -3.05 to -1.43, class Ⅳ), reduced disease severity in atopic dermatitis (SMD -0.41, -0.65 to -0.17, class Ⅳ), and decreased clinical scores in urticaria (SMD -3.63, -5.72 to -1.54, class III). However, no significant effect was observed for vitamin D supplementation on asthma or food allergy. Prenatal vitamin D supplementation showed no significant preventive effect on the risk of offspring allergic rhinitis, atopic dermatitis, or asthma. Conclusions: Lower vitamin D levels are consistently associated with several allergic diseases. The available evidence suggests that vitamin D supplementation demonstrates beneficial effects on symptom improvement for specific diseases (allergic rhinitis, atopic dermatitis, urticaria), but its efficacy is disease-specific. Future research requires greater standardization and precision to clarify the exact role and clinical utility of vitamin D in the prevention and management of different allergic diseases. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.