Risk Factors and Predictive Value of Sepsis in Patients with Liver Abscess.

Objective: To investigate the factors associated with sepsis in patients with liver abscess (LA) and assess their predictive value for the early identification of high-risk patients. Methods: Clinical data from 798 patients with LA were retrospectively analyzed. LA was diagnosed according to established diagnostic criteria, and sepsis was defined according to the Sepsis-3 criteria. Patients were divided into a sepsis group (n = 558) and a non-sepsis group (n = 240). Baseline characteristics, laboratory parameters, microbiological features, treatment details, and clinical outcomes were compared between the two groups. Multivariable logistic regression analysis was performed to identify factors associated with sepsis, and receiver operating characteristic (ROC) curve analysis was used to evaluate their predictive value. Results: Patients in the sepsis group were younger and had a higher prevalence of hepatobiliary surgery history and a higher incidence of jaundice than those in the non-sepsis group ( Conclusion: Sepsis in patients with LA is closely associated with a history of hepatobiliary surgery, elevated Cr and TBIL levels, and decreased PLT. A combined predictive model based on TBIL, Cr, and PLT demonstrated good discriminative ability and may facilitate the early identification of patients at high risk of sepsis, thereby supporting risk stratification and clinical decision-making.