ArticleFrontiers in cardiovascular medicine2026
Several antiplatelet gene SNPs, their haplotypes and
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the impact of single nucleotide polymorphisms (SNPs) and haplotypes of antiplatelet drug metabolism-related genes- Methods: This real-world study enrolled 1,108 participants, including PCAD patients and angiography-referred controls without obstructive CAD. Twelve SNP loci were genotyped using PCR amplification followed by digoxigenin-based colorimetric detection, including Results: Significant differences in genotype and allele frequencies between PCAD patients and controls were observed for rs12769205, rs3758580, rs4917623 and rs1330344 ( Conclusion: Polymorphisms, haplotypes and interactions of antiplatelet drug-related genes significantly influence the risk of PCAD. Environmental exposures should be considered in early warning and individualized prevention of PCAD.
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