ArticleClinical interventions in aging2026
Muscle Ultrasound Parameters and Cognitive Function in H‑type Hypertension: A Cross-Sectional Study.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: H-type hypertension is associated with an increased risk of cognitive impairment, but the relationship between muscle ultrasound parameters and cognitive function in this population remains unclear. This cross-sectional study investigated the association between muscle ultrasound parameters and cognitive function in patients with H-type hypertension and sought to identify ultrasound parameters associated with cognitive status. Methods: This cross-sectional study included 125 patients with H-type hypertension. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Participants were classified into non-cognitive impairment (n = 68) and cognitive impairment (n = 57) groups. Muscle thickness (MT), muscle cross-sectional area (MCSA), shear wave velocity (SWV), and pennation angle (PA) were measured at selected upper- and lower-limb muscles. Partial correlation analysis, multivariable linear regression, and binary logistic regression were performed to examine associations between ultrasound parameters and cognitive status. Results: Compared with the non-cognitive impairment group, the cognitive impairment group had significantly lower MT and MCSA at multiple sites, including the biceps brachii, brachioradialis, rectus femoris, and lateral gastrocnemius (all Conclusion: Reduced rectus femoris MT is independently associated with poorer cognitive function and the presence of cognitive impairment in patients with H-type hypertension. Rectus femoris MT may serve as a useful adjunctive ultrasound marker of concurrent cognitive status, but prospective studies are needed to determine its clinical utility.
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