Evidence map›Paper›PMID 42445622›Full record

ArticleAmerican journal of diagnostic imaging2026

Using Imaris to rigorously track PET-defined sites of lung inflammation in

Estefania Hurtado, Xavier Alvarez, Deepak Kaushal, Smriti Mehra, Vitaly V Ganusov

Abstract read
In one paragraph

Article in American journal of diagnostic imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Estefania HurtadoHost-Pathogen Interactions (HPI) program, Texas Biomedical Research Institute, San Antonio, TX 78245.
Xavier AlvarezHost-Pathogen Interactions (HPI) program, Texas Biomedical Research Institute, San Antonio, TX 78245.
Deepak KaushalHost-Pathogen Interactions (HPI) program, Texas Biomedical Research Institute, San Antonio, TX 78245.
Smriti MehraHost-Pathogen Interactions (HPI) program, Texas Biomedical Research Institute, San Antonio, TX 78245.
Vitaly V GanusovHost-Pathogen Interactions (HPI) program, Texas Biomedical Research Institute, San Antonio, TX 78245.

Funding

ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1M
Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9M
Myeloid and lymphoid immunity-specific mechanisms of IDO mediated immunosuppression and its reversal, during TBR01AI134245 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Smriti Mehra · 2018 to 2026
$6.2M
A STINGing vaccine for TBR01AI155346 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES, MEHRA, SMRITI · 2020 to 2024
$4.9M
Immune Correlates of Protection from TBR01AI134240 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2017 to 2022
$4.8M
SigH based attenuated, efficacious Mtb vaccines to protect against lethal TBR01AI138587 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI JAGANNATH, CHINNASWAMY, KAUSHAL, DEEPAK · 2018 to 2022
$4.4M
A Novel Th17-inducing Mucosal Vaccine for TuberculosisR01AI150043 · NIAID · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2020 to 2023
$3.4M
Mathematical modeling of Mycobacterium tuberculosis disseminationR01AI158963 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Vitaly V. Ganusov · 2022 to 2026
$3.2M
Modulating Indoleamines to Optimize Immunity in the Setting of Mtb/HIV Co-infectionR01AI181701 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Smriti Mehra · 2024 to 2026
$2.8M
Comparative genomic analysis of specificity to mosquitoes in Metarhizium pingshaense basis for improved biological controlR03AI135751 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI ST LEGER, RAYMOND J · 2018 to 2019
$152k
NIAID NIH HHS P30 AI168439NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI134240NIAID NIH HHS R01 AI134245NIAID NIH HHS R01 AI138587NIAID NIH HHS R01 AI150043NIAID NIH HHS R01 AI155346NIAID NIH HHS R01 AI158963NIAID NIH HHS R01 AI181701NIAID NIH HHS R03 AI135751
6 · The paper itself

Abstract

Background: Aerosol exposure of non-human primates ( Methods: Here we propose a pipeline for analysis of the same PET/CT scans using Imaris, a proprietary software typically used for analysis of fluorescent microscopy data. Results: We show that by using locations of spine vertebra (denoted as "landmarks") we can align serials scans of the same animal, and by using automated (with some manual corrections) image segmentation of PET scans in 3D as "surfaces", we can accurately define location of all sites of inflammation in the lung and lung-associated thoracic lymph nodes ( Conclusion: Our novel methodology allows for detailed and rigorous analyses of how features of PET-defined lesions in Mtb-exposed monkeys evolve over time and correlate with the outcome of infection and/or treatment.

Indexed as

Imaging dataImarisPET/CTPET tracersradioactivitySUVVivoQuant

Identifiers

PMID42445622
PMCPMC13358166

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.