ReviewNature and science of sleep2026
Loop Gain in Obstructive Sleep Apnea: From Physiological Endotype to Clinical Translation.
Review in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To define how loop gain can move from a physiological endotype to a clinically actionable metric in obstructive sleep apnea. Methods: This clinical translational narrative review identified relevant literature from PubMed, Web of Science, Embase, and reference/citation searching, focusing on adult obstructive sleep apnea studies related to loop gain physiology, assessment methods, treatment stratification, and clinical implementation. Results: Loop gain helps explain why patients with similar apnea-hypopnea index values may show different disease expression and treatment responses. Research-grade perturbation methods remain the physiological reference standard, whereas raw-polysomnography (PSG) modeling currently represents the most practical route for clinical deployment. Simplified screening tools and emerging automated approaches based on polygraphy, photoplethysmography, or respiratory inductance plethysmography may expand access, provided their outputs are interpreted within method-specific contexts. Clinically, elevated loop gain may inform pre-treatment restratification before surgery or oral appliance therapy, selection of oxygen or ventilatory-control-targeted pharmacotherapy, and interpretation of residual instability during continuous positive airway pressure. Conclusion: Loop gain is most useful as a selective decision-support metric rather than as an isolated physiological number. Staged implementation, method-specific reporting, and outcome-oriented studies are needed to determine when LG-guided stratification improves clinical decisions in obstructive sleep apnea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.