ReviewDrug design, development and therapy2026
Precision Endocrine-Based Combinations After CDK4/6 Inhibitor Progression in HR-Positive Metastatic Breast Cancer.
Review in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
CDK4/6 inhibitors combined with endocrine therapy (ET) has significantly improved progression-free (PFS) and overall survival (OS) in patients with hormone receptor-positive (HR+), HER2-negative breast cancer, however, most patients ultimately develop acquired resistance and experience disease progression. Historically, this transition marked the point at which chemotherapy was initiated; however, advances in molecular profiling and drug development have fundamentally altered this paradigm.Resistance to endocrine therapy is mediated by distinct and therapeutically actionable mechanisms, most notably
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