Evidence map›Paper›PMID 42445755›Full record

Observational studySaudi medical journal2026

Multidimensional Predictors of Disease Severity and Health Outcomes in Patients with Sickle Cell Disease:

Hind A Alzahrani, Ruba Omar Mohammed Almaghrabi, Raed Alharbi, Abdulaziz Saleh Alghamdi, Mohammad A Albanghali, Hanan E Alyahyawi, Abdulmohsen M Alruwetei, Besma Garah, Mohammed Alzahrani, Samar Hassan Hjar and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Saudi medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hind A AlzahraniDepartment of Basic Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.ORCID 0009-0008-9974-5665
Ruba Omar Mohammed AlmaghrabiLaboratory Medicine Department, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Raed AlharbiLaboratory Medicine Department, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Abdulaziz Saleh AlghamdiDepartment of Hematology, Laboratory, King Fahad Hospital, Al-Baha, Kingdom of Saudi Arabia.
Mohammad A AlbanghaliDepartment of Public Health, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Hanan E AlyahyawiLaboratory Medicine Department, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Abdulmohsen M AlruweteiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Besma GarahDepartment of Internal Medicine, Hematology, King Fahad Hospital, Al-Baha, Kingdom of Saudi Arabia.
Mohammed AlzahraniDepartment of Pediatric Emergency, Prince Meshari Bin Saud General Hospital, Al-Baha, Kingdom of Saudi Arabia.
Samar Hassan HjarDepartment of Hematology, Laboratory, King Abdulaziz Specialist Hospital, Al-Taif, Kingdom of Saudi Arabia.
Sana ShakerDepartment of Hematology, Laboratory, King Fahad Hospital, Al-Baha, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To describe the clinical, hematologic, and therapeutic characteristics of hospitalized adults with sickle cell disease (SCD) in the Al-Baha region and to identify factors that predict hospitalization as well as transfusion frequency. Methods: A retrospective observational analysis was conducted on 117 adults with confirmed SCD who were admitted to King Fahad Hospital-Al-Baha during 2022-2024. Demographic information, hematologic parameters, clinical features, hospitalization rate, transfusion history, and treatment protocols were collected from the electronic medical records. Statistical analyses (ANOVA, Kruskal-Wallis test, Chi-square tests, and Fisher's exact Test) were performed to compare between groups where applicable. Results: The cohort had a mean age of 30.6 years, with 63% being male. The average hemoglobin level was 8.57 g/dL, and there was an increase in hemoglobin S (76%) and a mean fetal hemoglobin (Hbf) of 6.74%. Patients were admitted and transfused an average of 5.21 and 5.91 times, respectively. Blood transfusion was significantly more common in males than in females ( Conclusion: Hospitalized adult SCD patients in Al-Baha present with significant anemia, frequent health care use, and substantial transfusion need. The more clinical symptoms appear simultaneously, the higher the hospitalization and transfusion rates are. These results underscore the clinical importance of symptom burden in adult SCD patients hospitalized.

Indexed as

Anemia, Sickle CellBlood TransfusionHospitalizationAdultFemaleFetal HemoglobinFolic AcidHemoglobin, SickleHumansHydroxyureaMaleRetrospective StudiesSaudi ArabiaSeverity of Illness IndexFetal HemoglobinFolic AcidHemoglobin, SickleHydroxyureaBlood transfusionHospitalizationHydroxyureaSickle cell diseaseSymptom burden

Identifiers

PMID42445755
PMCPMC13360555

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.