SynthesisFrontiers in nutrition2026
Effect of dietary interventions on kidney function in adults with obesity without chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
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Abstract
Objective: This study aimed to systematically evaluate the effects of dietary interventions on kidney function in adults with obesity without chronic kidney disease (CKD). Methods: A comprehensive literature search was conducted in PubMed, Web of Science, Embase, Cochrane Library for randomized controlled trials. Random-effects meta-analyses calculated standardized mean difference (SMD), with subgroup analyses by glomerular filtration rate (GFR) assessment method (estimated GFR [eGFR] vs. measured GFR [mGFR]). Results: Eighteen trials involving 1,438 participants were included. Dietary interventions showed no significant effect on GFR (SMD: 0.06; 95% CI: -0.20 to 0.32; Conclusion: Dietary interventions showed inconsistent effects across kidney function measures in adults with obesity without CKD. Although significant improvements were observed in certain kidney function-related indices (eGFR and CrCl), the available evidence did not indicate improved true filtration or reduced urinary albumin excretion. Importantly, these findings suggest that the apparent renal effects of dietary intervention depend on how kidney function is assessed. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261297927, CRD420261297927.
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