ReviewFrontiers in nutrition2026
Diet, mycobiome and virome: from mucosal immunity to gut-brain axis regulation.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
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Abstract
The gut microbiota plays a central role in regulating host metabolism, immune function and gut-brain axis signaling. Although bacterial communities have dominated microbiome research, the intestinal ecosystem also encompasses fungal communities and bacteriophages that can influence microbial functions and host physiology. This review examines how interactions among the mycobiome, virome (principally bacteriophages), and the bacterial microbiota shape metabolic signaling pathways relevant to gut-brain axis regulation. Fungal-bacterial and phage-bacterial interactions can remodel bacterial community function through ecological competition, biofilm formation, prophage induction and horizontal gene transfer. These multi-kingdom interactions modulate key microbial metabolites, including short-chain fatty acids, tryptophan-derived indole metabolites and bile acid intermediates, which act as major regulators of intestinal barrier integrity, immune responses and neuroimmune signaling. Disruption of these metabolic pathways may contribute to altered host signaling through receptors such as the aryl hydrocarbon receptor (AhR) and bile acid receptors, with downstream effects on intestinal inflammation and neuroimmune regulation. Diet is among the most influential determinants of this ecosystem, directly shaping microbiota bacterial metabolism, fungal growth and phage-bacteria interactions. Dietary patterns rich in fermentable fibers and bioactive compounds may promote beneficial microbial metabolic outputs, whereas Western-type diets and high sugar intake may favor ecological imbalances that disrupt microbial signaling pathways relevant to gut-brain axis regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.