ArticleJournal of asthma and allergy2026
Persistent Airflow Limitation in Asthma: Clinical Characteristics, Risk Factors, and Long-term Outcomes from a Multicenter Cohort Study.
Jung-Kyu Lee, Hyun-Woo Lee, Chang Hoon Lee, Joon Young Choi, Jong Geol Jang, Chin Kook Rhee, Yong Bum Park, Seong Yong Lim, Kwang Ha Yoo, Deog Kyeom Kim
Abstract read
In one paragraphArticle in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Jung-Kyu LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-5060-7255 Hyun-Woo LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-4379-0260 Chang Hoon LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-9960-1524 Joon Young ChoiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-6298-2204 Jong Geol JangDivision of Pulmonology and Allergy, Department of Internal Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Republic of Korea.ORCID 0000-0001-8040-5363 Chin Kook RheeDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-4533-7937 Yong Bum ParkDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea.ORCID 0000-0002-5814-6104 Seong Yong LimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-8098-3622 Kwang Ha YooDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-9969-2657 Deog Kyeom KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-1186-3728 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Background: Persistent airflow limitation (PAL) is an increasingly recognized asthma phenotype, but its prevalence, determinants, and prognostic significance in real-world settings remain unclear. This study evaluated the clinical characteristics and long-term outcomes associated with PAL and its severity in asthma. Methods: Multicenter analysis of combined retrospective and prospective cohorts in South Korea. PAL was defined as post-bronchodilator FEV Results: Among 849 patients with asthma, 640 (75.4%) had PAL. PAL was associated with older age, male sex, lower body mass index, higher smoking intensity, lower FEV Conclusion: PAL and its severity independently predict the risk of severe exacerbations and progressive lung function decline in asthma, underscoring PAL as a key marker of disease progression and a potential target for early intervention.
Indexed as
asthmaexacerbationlung functionpersistent airflow limitation
Identifiers
PMID42445813
PMCPMC13360822
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