Evidence map›Paper›PMID 42445814›Full record

ArticleJournal of experimental orthopaedics2026

Meniscal extrusion increases with age: Decade-specific magnetic resonance imaging reference values.

Riccardo Compagnoni, Rossella Ravaglia, Matteo Parmigiani, Alessio Maione, Filippo Pierfrancesco Calanna, Paolo Ferrua, Pietro Simone Randelli

Abstract read
In one paragraph

Article in Journal of experimental orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Riccardo CompagnoniDepartment of Biomedical, Surgical and Dental Sciences Università degli Studi di Milano Milan Italy.
Rossella RavagliaUniversity of Milan, School of Specialization in Orthopedics and Traumatology Milan Italy.ORCID https://orcid.org/0000-0002-9006-124X
Matteo Parmigiani2 ° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO Milan Italy.
Alessio Maione1° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO Milan Italy.
Filippo Pierfrancesco Calanna1° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO Milan Italy.
Paolo FerruaWeek Surgery, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO Milan Italy.
Pietro Simone Randelli1° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO Milan Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To establish decade-specific magnetic resonance imaging (MRI)-based reference values for the medial meniscal extrusion index (MEI) in adults without significant structural knee pathology and to assess associations with age and sex. The hypothesis was that decade-specific MEI values would increase with age, without meaningful sex-related differences, while remaining low in knees without significant structural abnormalities on MRI. Methods: In June 2025, knee MRI examinations from a single tertiary orthopaedic centre were retrospectively screened until 500 eligible knees were identified (100 per decade, ages 20-69; balanced by sex). Inclusion criteria were age 20-69 years, 1.5-T MRI, and no definite/moderate osteoarthritis on MRI. Exclusion criteria included root, radial or complex meniscal tears; significant focal chondral lesions; ligament injury; discoid meniscus; prior knee surgery; inflammatory disease; evident anatomical abnormalities; and marked bone marrow edema. MEI was measured on coronal images as the ratio of extruded medial meniscus to total medial meniscal width. Linear regression tested the association between age and MEI, including an age × sex interaction term. Reference values were reported per decade as mean, standard deviation (SD) and mean + 1 SD and + 2 SD. Interobserver reliability was assessed using the intraclass correlation coefficient (ICC). Results: MEI was positively associated with age ( Conclusions: MEI increased progressively with age in knees without significant structural pathology on MRI, with no meaningful sex-related differences. Decade-specific MEI reference intervals may support age-adjusted interpretation of isolated medial meniscal extrusion, particularly in older adults, while reinforcing its role as an adjunctive imaging finding. Level of Evidence: Level III, retrospective cohort study.

Indexed as

agingknee MRImeniscal extrusionmeniscal extrusion indexnormative values

Identifiers

PMID42445814
PMCPMC13361056

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.