SynthesisFrontiers in endocrinology2026
Meta-analysis of the effects of exercise intervention on glucose metabolism and body composition in patients with type 2 diabetes mellitus.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Objective: To systematically evaluate the effects of exercise intervention on glucose metabolism and body composition in patients with type 2 diabetes mellitus (T2DM). Methods: Relevant literature built up to May 8, 2026 was searched through Web of Science, PubMed, EMBASE, and Cochrane Library databases, and Meta-analysis was performed using RevMan 5.4 software, and the quality of the literature was evaluated using the Cochrane Risk of Bias Assessment Tool. A total of 16 randomized controlled trials involving 1401 samples were included. Results: Exercise intervention significantly reduced glycated hemoglobin in patients with T2DM (SMD = -0.46, 95% CI: -0.73 to -0.19, P = 0.0007). Subgroup analysis revealed that combined exercise produced greater improvements (SMD = -0.71, 95% CI: -0.95 to -0.47, P < 0.00001) compared to aerobic exercise alone (SMD = -0.32, 95% CI: -0.62 to 0.02, P = 0.04). Exercise intervention also significantly reduced fasting blood glucose (SMD = -0.52, 95% CI: -0.70 to -0.35, P < 0.00001). However, no statistically significant improvement was observed for the insulin resistance index (SMD = -0.18, 95% CI: -0.40 to 0.04, P = 0.11). Regarding body composition, exercise intervention resulted in a significant reduction in BMI after excluding an outlier study (SMD = -0.37, 95% CI: -0.61 to -0.12, P = 0.003) and significantly improved maximal oxygen uptake (VO Conclusion: Exercise intervention can effectively improve glucose metabolism and body composition in patients with T2DM, with mixed (aerobic combined with resistance) exercise showing superior effects on glycemic control compared to aerobic exercise alone. Exercise intervention serves as an important non-pharmacological intervention for the comprehensive management of T2DM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.