ArticleExperimental physiology2026
Metabolic pattern across energy imbalance: An exploratory metabolomics study of female body weight extremes including anorexia nervosa and athletes.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Metabolic pattern across energy imbalance: An exploratory metabolomics study of female body weight extremes including anorexia nervosa and athletes.Experimental physiology · 2026Article
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7 authors.
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Abstract
In anorexia nervosa (AN), prolonged metabolic adaptation to severe energy deficiency can impair treatment efficacy. Similarly, low energy availability poses a recognized risk to athletes, potentially compromising health and performance. This cross-sectional study aimed to characterize the plasma metabolic pattern of females with varying physical conditions, including AN patients, athletes, and normal weight, overweight and obese females. Non-targeted metabolomics was applied to plasma samples from 107 females aged 18-40 years. Body fat was assessed via ultrasound and bioimpedance analysis. Nutritional intake, physical activity and clinical parameters were evaluated through standardized assessments. Sixty metabolites related to lipid, phospholipid and amino acid metabolism differed significantly between groups (ANOVA, false discovery rate q < 0.05). AN patients showed reduced long-chain free fatty acids, medium-chain acylcarnitines, etherphospholipids and branched-chain amino acids (BCAAs) (Cohen's d < -0.5), alongside increased lysophospholipids and glycerophosphocholine (d > 0.6). Athletes exhibited a similar though less pronounced pattern, with preserved BCAA levels, while overweight and obese individuals displayed opposing patterns. Metabolites including fatty acids, acylcarnitines, BCAAs and phospholipids positively correlated with body fat (r
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