ArticleJournal of assisted reproduction and genetics2026
The diagnostic value and molecular mechanism of miR-199a-5p in recurrent spontaneous abortion.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
purposeRecurrent spontaneous abortion (RSA) endangers women's health with a 5%-15% clinical incidence. Exploring the diagnostic capability of miR-199a-5p in RSA and its role in the function of trophoblast cells.
methodsqRT-PCR detected miR-199a-5p and E2F3 expression; correlation and Logistic regression analyses clarified their clinical relevance. Western blot, dual-luciferase reporter assay, CCK-8, and Transwell assays were used to verify the targeting relationship between miR-199a-5p and E2F3, and their regulatory effects on trophoblast biological functions and EMT.
resultsmiR-199a-5p level in patients with RSA is significantly decreased, and it has good diagnostic efficacy (AUC = 0.804, 95% CI: 0.724-0.883, sensitivity: 76.2%, specificity: 79.6%). Furthermore, a multivariate model combining miR-199a-5p with clinical parameters achieved an AUC of 0.903, with 85.2% sensitivity and 84.1% specificity. miR-199a-5p is an independent risk factor for RSA, negatively correlated with E2F3 and inflammatory markers, and is positively correlated with reproductive hormones. miR-199a-5p directly targets E2F3. Overexpression of miR-199a-5p promotes the function of trophoblast cells, while overexpression of E2F3 reverses these effects.
conclusionsmiR-199a-5p shows promise as a diagnostic marker for RSA, modulates trophoblast functions and EMT by targeting E2F3, participates in RSA progression and provides a novel therapeutic target.
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