Evidence map›Paper›PMID 42447476›Full record

ReviewRevista medica del Instituto Mexicano del Seguro Social2026

[Merkel cell carcinoma: current surgical approaches and multidisciplinary treatment].

Aldair Romero-López, Alexa Herrera-Ramírez, Gabriel Pérez-Esparza, Ana Laura Juárez-Carrera, José Francisco Cruz-Vargas

Abstract readEnglish AbstractReview
In one paragraph

Review in Revista medica del Instituto Mexicano del Seguro Social, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aldair Romero-LópezInstituto Mexicano del Seguro Social, Hospital General Regional No. 1 "Ignacio García Téllez", Servicio de Cirugía general. Orizaba, Veracruz, México.ORCID 0009-0007-4798-6523
Alexa Herrera-RamírezInstituto Mexicano del Seguro Social, Hospital General Regional No. 1 "Ignacio García Téllez", Servicio de Cirugía general. Orizaba, Veracruz, México.ORCID 0009-0007-9944-876X
Gabriel Pérez-EsparzaInstituto Mexicano del Seguro Social, Hospital Rural Coscomatepec, Servicio de Cirugía general. Coscomatepec de Bravo, Veracruz, México.ORCID 0009-0009-5897-2842
Ana Laura Juárez-CarreraInstituto Mexicano del Seguro Social, Hospital Rural Coscomatepec, Servicio de Cirugía general. Coscomatepec de Bravo, Veracruz, México.ORCID 0009-0003-2129-2110
José Francisco Cruz-VargasInstituto Mexicano del Seguro Social, Hospital Rural Coscomatepec, Servicio de Cirugía general. Coscomatepec de Bravo, Veracruz, México.ORCID 0009-0000-2740-8346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine tumor with poor prognosis, requiring precise surgical management within a multidisciplinary approach. We conducted a narrative review with a structured literature search in biomedical databases (PubMed, Embase, Scopus, Web of Science) and official guidelines (NCCN, ESMO). Thirty high-quality and clinically relevant articles were selected based on methodological rigor and applicability. Wide local excision with 1-2 cm margins remains the standard of care for localized disease. Sentinel lymph node biopsy should be performed in all clinically node-negative cases, and complete lymphadenectomy is reserved for patients with confirmed nodal involvement or symptomatic disease. While surgery is essential, it is insufficient alone and must be integrated into a multidisciplinary model involving accurate staging, oncologic follow-up, and immunotherapy in advanced stages. This review highlights the crucial role of the surgeon as an active member of the comprehensive care team to improve survival and quality of life in patients with MCC.

Indexed as

Carcinoma, Merkel CellSkin NeoplasmsCombined Modality TherapyHumansLymph Node ExcisionNeoplasm StagingNon-Melanoma Skin NeoplasmsPatient Care TeamSentinel Lymph Node BiopsyCarcinoma de Células de MerkelCarcinoma, Merkel CellGanglio Linfático CentinelaNeoplasias CutáneasRadioterapiaRadiotherapySentinel Lymph NodeSkin Neoplasms

Identifiers

PMID42447476
PMCPMC13400007

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.