ArticleBone & joint research2026
Functionalizing biomaterials for osseointegration - microRNAs at the crossroads of bone formation and immune modulation.
Article in Bone & joint research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
3 authors.
Funding
Abstract
MicroRNAs (miRNAs) play an important role in post-transcriptional gene regulation by binding to messenger RNA and thereby modulating protein synthesis and affecting cellular functions such as proliferation and apoptosis. In bone biology, miRNAs influence osseointegration, a process vital to the long-term success of orthopaedic implants. This process involves coordinated phases of inflammation, bone formation, and remodelling, which are regulated by miRNA-mediated signalling networks. miRNAs contribute to the regulation of osteoblast and osteoclast activity, as well as macrophage-mediated immune responses, thereby influencing bone regeneration and integration with implant surfaces. This review summarizes current insights into the role of miRNAs at the bone-implant interface, focusing particularly on their involvement in immune modulation and bone tissue formation. Furthermore, it explores emerging strategies for the local delivery of miRNAs to enhance implant integration, highlighting their therapeutic potential in improving orthopaedic outcomes.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.