Evidence map›Paper›PMID 42448558›Full record

ReviewTrends in immunology2026

Biomaterial-guided macrophage modulation: Therapeutic engineering of immune microenvironments.

Jordan Popov, Andreas Patsalos, Hai-Quan Mao, Laszlo Nagy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Special Issue "Flow Cytometry: Applications and Challenges".International journal of molecular sciences · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jordan PopovDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, Saint Petersburg, FL, USA.
Andreas PatsalosInstitute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, Saint Petersburg, FL, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hai-Quan MaoDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA; Translational Therapeutic and Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laszlo NagyDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, Saint Petersburg, FL, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H4012, Hungary. Electronic address: lnagy@jhmi.edu.

Funding

Intracellular trafficking of the essential signaling metabolite heme in myeloid cells: impact on physiology and diseaseR01DK138430 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI Laszlo Nagy, Enrique Saez · 2024 to 2026
$3.0M
A nanofiber-hydrogel composite plug for perianal fistula repairR01DK135269 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Hai-Quan Mao, Florin Selaru · 2023 to 2026
$2.6M
DHA-derived resolvin production andsignaling in tissue repair macrophages in metabolic diseaseR01DK124782 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI NAGY, LASZLO, SPITE, MATTHEW R · 2020 to 2023
$2.3M
Nuclear receptor, PPARg in macrophage polarization, hyperinflammatory gene expression and lung injuryR01HL170426 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Laszlo Nagy · 2024 to 2026
$1.9M
BACH1 as a novel pioneer repressor in macrophages: impact on homeostasis and inflammationR01AI185363 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Laszlo Nagy · 2024 to 2026
$1.7M
PPARgamma as an architectural regulator of gene expression in endocrine signalingR01DK115924 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI NAGY, LASZLO · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL170426NIAID NIH HHS R01 AI185363NIDDK NIH HHS R01 DK115924NIDDK NIH HHS R01 DK124782NIDDK NIH HHS R01 DK135269NIDDK NIH HHS R01 DK138430
6 · The paper itself

Abstract

Macrophages are central regulators of immunity, tissue homeostasis, and repair, whose plasticity enables them to integrate cues from their local microenvironment. Dysregulated macrophages contribute to chronic inflammation, fibrosis, impaired wound healing, and tumor progression. Biomaterials enable the modulation of macrophages through localized delivery of immunomodulatory signals and by creating instructive microenvironments. In this review, we examine macrophage-biomaterial interactions, emphasizing how surface chemistry, topography, mechanics, porosity, and degradation profiles shape macrophage recruitment and phenotype. We discuss emerging strategies for macrophage modulation, including programmable systems that provide spatiotemporal control over immune signaling. We further highlight how these applications can improve disease outcomes. Finally, we discuss design considerations, characterization, and translational challenges that must be overcome to advance macrophage-targeted biomaterials toward clinical implementation.

Indexed as

biomaterialsdrug deliveryimmunoengineeringmacrophagesregenerative inflammation

Identifiers

PMID42448558
PMCPMC13374712

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.