Evidence map›Paper›PMID 42448565›Full record

ArticleGenes & development2026

TET1 noncatalytic activity shapes the chromatin landscape associated with de novo methylation establishment in the male germline.

Rexxi D Prasasya, Jean J Kim, Zhengfeng Liu, Rahul M Kohli, Marisa S Bartolomei

Abstract read
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Rexxi D PrasasyaDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID http://orcid.org/0000-0003-2828-3316
Jean J KimDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Zhengfeng LiuDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID http://orcid.org/0000-0003-1111-740X
Rahul M KohliDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID http://orcid.org/0000-0002-7689-5678
Marisa S BartolomeiDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; bartolom@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-9410-5222

Funding

Role of TET1 in germ cell reprogramming and developmentR01GM146388 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 2022 to 2025
$1.2M
TET-mediated DNA Demethylation Mechanisms and Epigenome Engineering ApplicationsR01GM158685 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Rahul Manu Kohli · 2025 to 2026
$731k
Molecular determinants of sex-specific DNA methylation signature acquisition in the mammalian germlineK99HD112543 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI PRASASYA, REXXI DIPTYA · 2023 to 2024
$240k
NICHD NIH HHS K99 HD112543NIGMS NIH HHS R01 GM146388NIGMS NIH HHS R01 GM158685
6 · The paper itself

Abstract

In the germline, DNA methylation is globally erased in primordial germ cells (PGCs), enabling establishment of sex-specific methylomes in prospermatogonia or oocytes. The catalytic activity of TET1 is required for complete demethylation in PGCs, yet sperm from

Indexed as

ChromatinDNA-Binding ProteinsDNA MethylationProto-Oncogene ProteinsSpermatozoaAnimalsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AGerm CellsHistonesMaleMiceChromatinDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADnmt3a protein, mouseHistonesProto-Oncogene ProteinsTET1 protein, mousecatalytic and noncatalytic activity of TET1germline methylation establishmentTET1 and chromatin landscape

Identifiers

PMID42448565
PMCPMC13374711

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.