Evidence map›Paper›PMID 42448680›Full record

ArticleNature communications2026

High ambient temperature activates a neural circuit for gut glucose uptake in male mice.

Ruihua Li, Mingming Liu, Zhiqi Zhang, Qin Zhu, Mingsi Chen, Jiaxin Liu, Linghui Pan, Aru Su, Qian Zhou, Renli Qi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ruihua Li *State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Mingming Liu *State Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Zhiqi Zhang *Institute for Agro-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, China.
Qin ZhuState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Mingsi ChenState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Jiaxin LiuState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Linghui PanState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Aru SuState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Qian ZhouState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Renli QiChongqing Academy of Animal Science, Chongqing, China.
Zuohua LiuChongqing Academy of Animal Science, Chongqing, China.
Ruifan WuState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.ORCID http://orcid.org/0000-0003-4917-5197
Songbo WangState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Lina WangState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.ORCID http://orcid.org/0000-0001-8133-3349
Gang ShuState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.ORCID http://orcid.org/0000-0002-1321-4396
Pingwen XuDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois Chicago, Chicago, IL, USA. pingwenx@uic.edu.ORCID http://orcid.org/0000-0001-9363-4114
Qingyan JiangState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China. qyjiang@scau.edu.cn.ORCID http://orcid.org/0000-0003-3466-2443
Canjun ZhuState Key Laboratory of Swine and Poultry Breeding Industry and Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China. canjunzhu@scau.edu.cn.ORCID http://orcid.org/0000-0002-1620-3414

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32102626National Natural Science Foundation of China (National Science Foundation of China) 32272954National Natural Science Foundation of China (National Science Foundation of China) 32372968National Natural Science Foundation of China (National Science Foundation of China) 32430098National Natural Science Foundation of China (National Science Foundation of China) 32522099National Natural Science Foundation of China (National Science Foundation of China) U21A20245-3
6 · The paper itself

Abstract

Heat stress triggers defensive energy demands to prevent cellular damage. Using male mice, we found that exposure to high ambient temperature (HAT) induces an increase in intestinal glucose absorption mediated by sodium/glucose cotransporter 1 (SGLT1). Glucose supplementation alleviated HAT-induced physiological damage in mice. Mechanistically, we found that blocking intestinal vagal motor nerve transmission eliminated HAT's stimulatory effects on intestinal glucose absorption. This suggests that cholinergic motor neurons originating from the dorsal motor nucleus of the vagus (DMV

Indexed as

GlucoseHot TemperatureAnimalsCholinergic NeuronsCorticotropin-Releasing HormoneIntestinal AbsorptionMaleMiceMice, Inbred C57BLNeuronsParaventricular Hypothalamic NucleusPreoptic AreaSodium-Glucose Transporter 1Vagus NerveCorticotropin-Releasing HormoneGlucoseSlc5a1 protein, mouseSodium-Glucose Transporter 1

Identifiers

PMID42448680
PMCPMC13490476

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.