ArticleNature communications2026
Dorsal horn DCC amplification loop induced by endplate osteoclasts generates chronic nociplastic low back pain in male mice.
Dayu Pan, Mengxi Shen, Elizabeth Abatan, Jinjian Zheng, Philip Nasser, Damien M Laudier, Chao Kong, Lei Yan, Zhaozhu Qiu, James C Iatridis and 4 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
14 authors.
Dayu PanDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mengxi ShenDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth AbatanDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jinjian ZhengDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Philip NasserDepartment of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Damien M LaudierDepartment of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chao KongDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Junying ZhengDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bradley K TaylorDepartment of Anesthesiology and Perioperative Medicine, Pittsburgh Center for Pain Research, Pittsburgh Project to end Opioid Misuse, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-5080-6120 Funding
Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2021 to 2025
$9.2MSialylation of TLR2 Induces Osteoclast Fusion and Th 17 differentiation During AgingR01AG076783 · NIA · JOHNS HOPKINS UNIVERSITY · PI Xu Cao · 2022 to 2026
$2.4MSubchondral Bone Cavities in Osteoarthritis PainR01AG068997 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU, GUAN, YUN · 2024 to 2024
$621kNIA NIH HHS P01 AG066603NIA NIH HHS R01 AG068997NIA NIH HHS R01 AG076783U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P01AG066603U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG068997U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG076783
6 · The paper itselfAbstract
Spine degeneration is associated with low back pain (LBP), a major cause of disability and functional decline. However, effective therapies for non-specific LBP remain limited because its underlying mechanisms are poorly understood. Here, we show that spine degeneration induces netrin-1 secretion in porous endplates to activate DCC signaling in dorsal root ganglion (DRG) neurons in both LBP and naturally aged male mice. Conditional loss of netrin-1 in Trap
Indexed as
DCC ReceptorNociplastic PainOsteoclastsSpinal Cord Dorsal HornAnimalsGanglia, SpinalMaleMiceNetrin-1Posterior Horn CellsSignal TransductionDcc protein, mouseDCC ReceptorNetrin-1Ntn1 protein, mouse
Identifiers
PMID42448693
PMCPMC13486690
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