Evidence map›Paper›PMID 42448719›Full record

ArticleNature communications2026

Reversal of protein chemical aging by enzymatic deglycation.

Narisa Trabosh, Jason Smith, Maggie Yun-Hsuan Hsu, Sudipta Panja, Ram Nagaraj, Niclas Olsson, Fiona E McAllister, Aaron Cravens

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Narisa TraboshRevel Pharmaceuticals Inc., San Francisco, CA, USA.ORCID 0009-0004-5311-6856
Jason SmithCalico Life Sciences LLC, South San Francisco, CA, USA.ORCID 0009-0003-9809-9554
Maggie Yun-Hsuan HsuRevel Pharmaceuticals Inc., San Francisco, CA, USA.ORCID 0000-0002-3697-5366
Sudipta PanjaSchool of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Ram NagarajSchool of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-4737-8847
Niclas OlssonCalico Life Sciences LLC, South San Francisco, CA, USA.ORCID 0000-0002-9746-0542
Fiona E McAllisterCalico Life Sciences LLC, South San Francisco, CA, USA.ORCID 0000-0002-7862-6711
Aaron CravensRevel Pharmaceuticals Inc., San Francisco, CA, USA. aaron@revelpharmaceuticals.com.ORCID 0009-0007-3932-6613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The accumulation of advanced glycation end products (AGEs) in long-lived proteins is a hallmark of mammalian aging and implicated as a driver of metabolic dysfunction. Among these adducts, N

Indexed as

AgingGlycation End Products, AdvancedLysineProteinsDirected Molecular EvolutionGlycosylationHumansOxidation-ReductionProtein EngineeringGlycation End Products, AdvancedLysineN(6)-carboxymethyllysineProteins

Identifiers

PMID42448719
PMCPMC13369945

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.