Evidence mapPaperPMID 42448793Full record

ArticleNature metabolism2026

Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis.

Jiayin Tang, Gerard Pernes, Brenda Nakagaki, Nhien Tran, Laura Bokor, Fran Prenen, Mingyang Yi, Avery E Robertson, Rachel Cronin, Mohamad Sarmini and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiayin TangDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Gerard PernesDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6524-3255
Brenda NakagakiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nhien TranDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5009-9323
Laura BokorDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Fran PrenenDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5431-1715
Mingyang YiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Avery E RobertsonDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0009-0004-3586-0999
Rachel CroninDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Mohamad SarminiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jacob PierscianowskiDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.
Victoria RobertsDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Birgitta A RybackDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Carl D NovinaDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Karine AuclairDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.
Haopeng XiaoDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4166-647X
Evanna L MillsDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. evanna_mills@dfci.harvard.edu.ORCID http://orcid.org/0000-0003-0447-8995

Funding

American Heart Association (American Heart Association, Inc.) 25POST1375498American Heart Association (American Heart Association, Inc.) 25PRE1357302G. Harold and Leila Y. Mathers Foundation (G. Harold & Leila Y. Mathers Foundation) MF-2204-02617U.S. Department of Health & Human Services | National Institutes of Health (NIH) 4R00 DK123321-05
6 · The paper itself

Abstract

Thermogenic brown and beige adipose tissues are important in maintaining metabolic health because of their distinct ability to catabolize stored fat and circulating glucose in futile cycles

Identifiers

PMID42448793

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.