ArticleCommunications medicine2026
Radioactive ion beam range adaptation in mouse tumors using in-beam PET.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
30 authors.
Funding
Abstract
backgroundTreatment adaptation is particularly critical in particle therapy, where even small range deviations can compromise target coverage or lead to unintended dose delivered to surrounding healthy tissues. In-beam positron emission tomography (PET) has emerged as a promising approach for range verification during irradiation with protons or stable carbon ion beams. However, its clinical use is limited by low signal-to-noise ratio and by the spatial mismatch between activity and dose distributions, reducing verification accuracy and limiting timely intervention.
methodsWe used radioactive ion beams for real-time range adaptation in 10 weeks old C3H/ HeNRj female mice bearing LM8-osteosarcoma tumors. Three
resultsDynamic repositioning of the
conclusionsWe provide the first demonstration that in-beam imaging of radioactive ion beams can enable real-time range-guided radiotherapy in a living organism. These findings establish radioactive ion beams as a promising platform for precision range-guided particle therapy.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.