Evidence mapPaperPMID 42449191Full record

ArticleChemistry & biodiversity2026

Design and Synthesis of Hesperidin Derivatives With Anti-Inflammatory Potential.

Hong-Yue Ma, Xian-Fei Chen, Jing Wei, Jun-Hao Wang, Hong-Dan Yang, Lu Ran, Ai-Yang Liu, Xu Chang, Jian-Jia Liang, Zhang-Shuang Deng

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hong-Yue MaHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.
Xian-Fei ChenHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.
Jing WeiHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.
Jun-Hao WangHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.
Hong-Dan YangHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.
Lu RanHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.
Ai-Yang LiuHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.
Xu ChangAngel Yeast Co. Ltd., Yichang, China.
Jian-Jia LiangHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.ORCID https://orcid.org/0009-0001-3500-4576
Zhang-Shuang DengHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, China.

Funding

Hubei Provincial Department of Education D20241205Hubei Provincial Natural Science Foundation Joint Fund for Innovation and Development Project of Yichang 2024AFD135Hubei Provincial Natural Science Foundation Joint Fund for Innovation and Development Project of Yichang 2026AFC0417National Natural Science Foundation of China 82304312
6 · The paper itself

Abstract

Hesperidin is the primary active constituent of citrus fruits and exhibits a wide range of pharmacological activities. To identify more effective anti-inflammatory compound, 22 novel hesperidin derivatives incorporating fatty and cinnamic acid groups were designed and synthesized. Among them, compound B8 demonstrated the most potent inhibitory effect against LPS-induced NO production in RAW264.7 macrophages (IC

Indexed as

Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalDrug DesignHesperidinAnimalsLipopolysaccharidesMacrophagesMiceMolecular Docking SimulationMolecular StructureNitric OxideNLR Family, Pyrin Domain-Containing 3 ProteinRAW 264.7 CellsStructure-Activity RelationshipAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalHesperidinLipopolysaccharidesNitric OxideNLR Family, Pyrin Domain-Containing 3 Proteinanti‐inflammatory activityhesperidinmolecular dockingstructure‐activity relationships

Identifiers

PMID42449191
PMCPMC13369389

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.