ArticleChinese medicine2026
Rhein from a traditional herbal formula attenuates hepatic fibrosis via ALDH1A3-mediated retinoic acid metabolism.
Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHepatic fibrosis is a prevalent outcome of chronic liver diseases. Although activation of hepatic stellate cell (HSC) is a primary driver of fibrogenesis, therapeutic strategies targeting retinoic acid (RA) metabolism in HSCs remain insufficiently investigated. This study aimed to elucidate the material basis of Huanggen formula (FHG), identify its principal bioactive constituents, and clarify the underlying antifibrotic mechanisms.
methodThe antifibrotic efficacy of FHG was assessed in a CCl
resultsFHG markedly alleviated metabolic disturbances and histopathological injury in fibrotic mice. Metabolomic analysis identified anthraquinones and flavonoids as the principal active classes, with rhein exhibiting potent anti-HSC activation effects. Rhein suppressed LX-2 activation, extracellular matrix (ECM) accumulation, and migration, and mitigated CCl
conclusionRhein is a key antifibrotic constituent of FHG and suppresses hepatic fibrosis by targeting ALDH1A3 and restoring RA metabolism. The ALDH1A3-ATRA axis represents a central mechanism and a promising therapeutic target.
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