Evidence map›Paper›PMID 42449464›Full record

ArticleBorderline personality disorder and emotion dysregulation2026

The role of different forms of adverse childhood experiences in borderline personality disorder: results from a network analysis including clinical and non-clinical populations.

Ruben Vonderlin, Büsra Senyüz, Carola Claus, Saskia Mahalingam, Anna Schulze, Stefan Koch, Ulrich Voderholzer, Christian Schmahl, Jürgen Margraf, Tobias Teismann and 5 more

Abstract read
In one paragraph

Article in Borderline personality disorder and emotion dysregulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruben VonderlinDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, D-68159, Mannheim, Germany. ruben.vonderlin@zi-mannheim.de.
Büsra SenyüzDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, D-68159, Mannheim, Germany.
Carola ClausMental Health Research and Treatment Center, Ruhr-University Bochum, Bochum, Germany.
Saskia MahalingamDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, D-68159, Mannheim, Germany.
Anna SchulzeGerman Center for Mental Health (DZPG), Partner Site Mannheim - Heidelberg, Ulm, Germany.
Stefan KochSchoen Clinic Roseneck, Prien am Chiemsee, Germany.
Ulrich VoderholzerSchoen Clinic Roseneck, Prien am Chiemsee, Germany.
Christian SchmahlDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, D-68159, Mannheim, Germany.
Jürgen MargrafMental Health Research and Treatment Center, Ruhr-University Bochum, Bochum, Germany.
Tobias TeismannMental Health Research and Treatment Center, Ruhr-University Bochum, Bochum, Germany.
Nikolaus KleindienstDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, D-68159, Mannheim, Germany.
Tali BoritzDepartment of Psychology, York University, Toronto, ON, Canada.
Shelley McMainCentre for Addiction and Mental Health, Borderline Personality Disorder Clinic, Toronto, ON, Canada.
Martin BohusDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, D-68159, Mannheim, Germany.
Stefanie LisDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, D-68159, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBorderline Personality Disorder (BPD) has been associated with a range of adverse experiences, including emotional, physical, and sexual abuse, neglect, invalidation, bullying, and unpredictable environments during childhood and adolescence (ACE). While these different forms of ACE often co-occur, most research has examined them in isolation, leaving unclear their interrelations and specific significance for BPD psychopathology.

objectiveThis study investigates the level of different forms of ACE exposure in BPD and clinical controls, whether they are differentially related to the severity of BPD symptoms and how they are inter-related with each other.

methodsCross-sectional data were collected from individuals diagnosed with BPD (n = 171), clinical controls (CC; n = 93), and non-clinical controls (NC; n = 73). BPD symptoms were measured using the BSL-23, while different types of ACE were assessed using the CTQ (abuse/neglect), ICES (invalidation), QUIC (unpredictability), and BSA (bullying). Graph-theoretical network analyses were conducted across groups to investigate associations between BPD symptom severity and ACE types, as well as interrelationships among ACEs. Data-driven community detection was applied to identify clusters of closely connected ACE types.

resultsThe BPD group showed higher ACE severity across all forms of ACE compared to CC and NC groups. Network analysis revealed unique associations between BPD symptom severity and emotional abuse, peer bullying, parental unpredictability, and lack of safety and security. Examination of interrelationships among ACE types resulted in a five-cluster solution demonstrating a complex pattern of unique associations.

conclusionsThis study advances our understanding of how different forms of ACE relate to BPD psychopathology and how they are interrelated with each other. The findings suggest that the impact of ACE extends beyond physical and sexual abuse to include relational and environmental adversities with relevance for BPD symptom severity in adulthood.

Indexed as

AbuseBorderline personality disorderBullyingMultivariate analysisNeglectNetwork-analysisTraumatic invalidationUnpredictability

Identifiers

PMID42449464
PMCPMC13371558

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.