Evidence mapPaperPMID 42449637Full record

ReviewCancers2026

Targeting Sirtuins in Thyroid Cancer: Mechanisms, Drug Development, and Emerging Roles in Tumor Immunity and Ferroptosis.

Ki Ju Cho, Ji Hyun Seo, Hayeong Kwon, Seung-Jun Lee, Young-Sool Hah, Jung Je Park

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ki Ju ChoDepartment of Otorhinolaryngology, Myongji Hospital, Hanyang University Medical Center, 55 Hwasu-ro 14 beon-gil, Goyang 10475, Republic of Korea.ORCID 0000-0002-1414-6655
Ji Hyun SeoInstitute of Medical Science, Gyeongsang National University College of Medicine, 816-15 Jinju-daero, Jinju 52727, Republic of Korea.
Hayeong KwonDepartment of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, 79 Gangnam-ro, Jinju 52725, Republic of Korea.ORCID 0009-0001-7582-4990
Seung-Jun LeeInstitute of Medical Science, Gyeongsang National University College of Medicine, 816-15 Jinju-daero, Jinju 52727, Republic of Korea.ORCID 0000-0002-9749-7505
Young-Sool HahInstitute of Medical Science, Gyeongsang National University College of Medicine, 816-15 Jinju-daero, Jinju 52727, Republic of Korea.ORCID 0000-0002-8571-2722
Jung Je ParkDepartment of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, 79 Gangnam-ro, Jinju 52725, Republic of Korea.ORCID 0000-0001-6325-0398

Funding

Gyeongsang National University Hospital GNUHBRIF-2025-0006National Research Foundation of Korea RS-2025-00562790
6 · The paper itself

Abstract

Thyroid cancer (TC) is the most common endocrine malignancy, with incidence increasing worldwide. Although most differentiated TCs have a favorable prognosis, radioiodine (RAI)-refractory differentiated thyroid cancer (DTC), BRAF inhibitor-resistant papillary thyroid cancer, and anaplastic thyroid cancer (ATC) remain major areas of unmet clinical need. The sirtuin (SIRT) family of NAD

Indexed as

anaplastic thyroid cancerBRAF V600Edesuccinylationferroptosisradioiodine refractorinessSIRT6SIRT7sirtuinthyroid cancertumor immunity

Identifiers

PMID42449637
PMCPMC13359528

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.