Evidence map›Paper›PMID 42449980›Full record

ArticleInternational journal of molecular sciences2026

Vitamin K2 Promotes Mitochondrial Structural and Functional Homeostasis to Ameliorate Alzheimer Pathology by Targeting the EGFR-Ras-ERK Signaling Axis.

Yanan Li, Hanyu Zhao, Jie Wu, Yan Hu, Juhong Pan, Asante Obed Frimpong, Biguo Xie, Wanming Yang, Manman Sun, Wenjun Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yanan LiDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Hanyu ZhaoDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Jie WuDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Yan HuDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Juhong PanDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Asante Obed FrimpongKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230026, China.
Biguo XieDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Wanming YangDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Manman SunKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230026, China.
Wenjun ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Peng WangDepartment of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230032, China.
Changsheng ShaoKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230026, China.ORCID 0000-0002-9070-1737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid (Aβ) accumulation and a breakdown of mitochondrial homeostasis. Vitamin K2 (VK2) has emerged as a potential neuroprotective agent, yet the specific molecular cascades linking its intervention to the restoration of mitochondrial integrity remain poorly understood. This study utilizes an AD

Indexed as

Alzheimer DiseaseMAP Kinase Signaling SystemMitochondriaras ProteinsVitamin K 2Amyloid beta-PeptidesAnimalsDisease Models, AnimalDrosophila melanogasterErbB ReceptorsHomeostasisHumansMembrane Potential, MitochondrialReactive Oxygen SpeciesSignal TransductionAmyloid beta-PeptidesErbB Receptorsras ProteinsReactive Oxygen SpeciesVitamin K 2Alzheimer’s diseaseDrosophila melanogasterEGFR-Ras-ERK signaling pathwaymolecular dockingnetwork pharmacologyVitamin K2

Identifiers

PMID42449980
PMCPMC13361347

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.