Evidence map›Paper›PMID 42449996›Full record

ArticleInternational journal of molecular sciences2026

Increased Mannosylation of Extracellular Vesicles in Long COVID Plasma as a Binding Target for

Miguel A Pesqueira Sanchez, Rosalia de Necochea Campion, Thomas Dalhuisen, Emily A Fehrman, Pahul S Chhabra, J Daniel Kelly, Jeffrey N Martin, Steven G Deeks, Timothy J Henrich, Michael J Peluso and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Miguel A Pesqueira SanchezAethlon Medical, Inc., San Diego, CA 92121, USA.
Rosalia de Necochea CampionAethlon Medical, Inc., San Diego, CA 92121, USA.ORCID 0009-0004-0148-2686
Thomas DalhuisenDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0001-9132-0496
Emily A FehrmanDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
Pahul S ChhabraDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
J Daniel KellyDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-7616-0321
Jeffrey N MartinDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
Steven G DeeksDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
Timothy J HenrichDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-6684-0622
Michael J PelusoDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
Steven P LaRosaAethlon Medical, Inc., San Diego, CA 92121, USA.ORCID 0000-0002-0773-2816

Funding

Aethlon Medical (United States) Not ApplicableNational Institutes of Health (NIH) R01AI141003; R01NS136197; K23AI157875PolyBio Research Foundation Not Applicable
6 · The paper itself

Abstract

There is no proven therapy for Long COVID, a post-acute condition characterized by persistent symptoms following SARS-CoV-2 infection. Extracellular vesicles (EVs) are emerging as mediators of disease pathogenesis through their molecular cargo. We investigated whether EV glycosylation is altered in Long COVID plasma and whether these vesicles can be selectively targeted using a glycan-binding affinity resin. Large (100-500 nm) and small (40-200 nm) EVs were isolated from post-acute COVID-19 plasma and analyzed by nanoparticle flow cytometry to assess surface glycosylation. Small EV capture assays were performed using

Indexed as

COVID-19Extracellular VesiclesMannosePlant LectinsGalanthusGlycosylationHumansMannose-Binding LectinsMicroRNAsPost-Acute COVID-19 SyndromeSARS-CoV-2MannoseMannose-Binding LectinsMicroRNAsPlant Lectinssnowdrop lectinextracellular vesiclesglycosylationimmunomodulationLong COVIDmicroRNA

Identifiers

PMID42449996
PMCPMC13361104

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.