Evidence map›Paper›PMID 42450025›Full record

ArticleInternational journal of molecular sciences2026

A Dysbiosis-Urolithin A Depletion-Low 6-Sulfatoxymelatonin Triad as a Composite Biomarker Framework Across Age-Related Vascular and Malignant Disease States.

Alexandre Tavartkiladze, Levan Tavartkiladze, Gaiane Simonia, Michel Burnier, Russel J Reiter, Ruite Lou, Dinara Kasradze, Nana Okrostsvaridze, Pati Revazishvili, Irine Andronikashvili and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandre TavartkiladzeDepartment of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia.ORCID 0000-0002-9589-7417
Levan TavartkiladzeInstitute for Personalized Medicine, 0186 Tbilisi, Georgia.
Gaiane SimoniaDepartment of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia.
Michel BurnierService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.ORCID 0000-0003-1283-8487
Russel J ReiterDepartment of Cellular & Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.ORCID 0000-0001-6763-4225
Ruite LouDepartment of Biotechnology, Foconsci Chemical Industry, Shaoxing 312000, China.
Dinara KasradzeInstitute for Personalized Medicine, 0186 Tbilisi, Georgia.
Nana OkrostsvaridzeInstitute for Personalized Medicine, 0186 Tbilisi, Georgia.
Pati RevazishviliDepartment of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia.
Irine AndronikashviliDepartment of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia.
Pirdara NozadzeDepartment of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, 0186 Tbilisi, Georgia.
Rusudan KhutsishviliInstitute for Personalized Medicine, 0186 Tbilisi, Georgia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urolithin A (UA) is a gut microbiota-derived postbiotic generated from dietary ellagitannins, while urinary 6-sulfatoxymelatonin (6-SMT) is a surrogate marker of nocturnal melatonin output. We explored whether dysbiosis, UA depletion, and low 6-SMT define an ordered biomarker pattern across healthy aging, salt-sensitive hypertension, and advanced cancer. In this pilot observational study, patients with advanced solid tumors were classified as Cancer Group 1 (higher aggressiveness;

Indexed as

CoumarinsDysbiosisMelatoninNeoplasmsAgedAgingBiomarkersFemaleHumansHypertensionMaleMiddle AgedPilot Projects3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one6-sulfatoxymelatoninBiomarkersCoumarinsMelatonin6-sulfatoxymelatoninadvanced cancercomposite biomarker triadcytokinesdysbiosisgut microbiotainflammagingmelatoninoxidative stresssalt-sensitive hypertensionurolithin A

Identifiers

PMID42450025
PMCPMC13361097

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.