Evidence map›Paper›PMID 42450032›Full record

ArticleInternational journal of molecular sciences2026

Quercetin Mitigates Oxidative Stress-Induced Premature Senescence in SH-SY5Y Neuronal-like Cells.

Federica Lina Salamone, Maria Sofia Molonia, Santi Trischitta, Antonella Saija, Francesco Cimino, Antonio Speciale

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Federica Lina SalamoneDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-8923-2120
Maria Sofia MoloniaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-8841-589X
Santi TrischittaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.
Antonella SaijaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-4186-3596
Francesco CiminoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-8954-4797
Antonio SpecialeDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-6135-3892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence is a biological process involved in aging and neurodegenerative disease progression, characterized by cell-cycle arrest, oxidative stress, persistent DNA damage, and development of a pro-inflammatory senescence-associated secretory phenotype (SASP). While replicative senescence results from exhaustion of cellular proliferative capacity, stress-induced premature senescence (SIPS) can be induced by multiple triggers, contributing to various pathological conditions. Among compounds reported to modulate cellular senescence, quercetin (QUE), a dietary flavonoid with antioxidant and anti-inflammatory properties, has emerged as a promising modulator of senescence-related pathways. This study investigated the protective effects of QUE against oxidative stress-induced senescence in SH-SY5Y neuronal-like cells. Cells were exposed to H

Indexed as

AntioxidantsCellular SenescenceNeuronsOxidative StressQuercetinCell Line, TumorHumansHydrogen PeroxideNF-E2-Related Factor 2Senescence-Associated Secretory PhenotypeSignal TransductionAntioxidantsHydrogen PeroxideNF-E2-Related Factor 2Quercetinneuronal senescenceNrf2 signalingoxidative stressquercetinSASPsenescence-modulating activitySH-SY5Y cells

Identifiers

PMID42450032
PMCPMC13360623

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.