Evidence mapPaperPMID 42450041Full record

ArticleInternational journal of molecular sciences2026

EGCG-Functionalized Selenium Nanoparticles Mitigate High-Fat Diet-Induced Hepatic Lipotoxicity Through Keap1/Nrf2 Redox Modulation and Transcriptional Regulation of AMPK/SIRT1/PGC-1α/MFN2-Associated Mitochondrial Homeostasis.

Fatma Al-Zahraa Sayed, Mennat Allah Maher, Mariam Elsayed Elborlosy, Mennat Allah Safwat, Mariam Sayed Mahmoud, Fatma Y Elmahdy, Romaysaa Tarek, Ahmed Hassan Ibrahim Faraag, Khaled Abuelhaded, Ahmed M Ashour and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fatma Al-Zahraa SayedSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Mennat Allah MaherSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Mariam Elsayed ElborlosySchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Mennat Allah SafwatSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Mariam Sayed MahmoudSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Fatma Y ElmahdySchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Romaysaa TarekSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Ahmed Hassan Ibrahim FaraagSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.ORCID 0000-0002-2568-6059
Khaled AbuelhadedSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.
Ahmed M AshourDepartment of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, P.O. Box 13578, Makkah 21955, Saudi Arabia.ORCID 0000-0002-2118-0499
Ali KhamesDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University, Sohag 82511, Egypt.
Khaled M Alam-ElDeinSchool of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt.ORCID 0009-0002-1140-8338
Mohamed H A GadelmawlaDepartment of Life Sciences, Faculty of Biotechnology, Sinai University, Kantara Branch, Ismailia 41636, Egypt.ORCID 0000-0002-1976-9480

Funding

Umm al-Qura University 25UQU4310007GSSR05
6 · The paper itself

Abstract

High-fat diet (HFD)-induced hyperlipidemia is an experimental metabolic condition characterized primarily by dysregulated serum lipid levels and hepatic lipid accumulation, with associated oxidative, inflammatory, mitochondrial, and cardiovascular alterations. This study investigated the therapeutic efficacy of epigallocatechin gallate (EGCG)-functionalized selenium nanoparticles (EGCG-SeNPs) against HFD-induced metabolic and hepatic injury, in comparison with free EGCG, sodium selenite (Na

Indexed as

CatechinDiet, High-FatMitochondriaNanoparticlesSeleniumAMP-Activated Protein KinasesAnimalsHomeostasisKelch-Like ECH-Associated Protein 1LiverMaleNF-E2-Related Factor 2Oxidation-ReductionOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRatsAMP-Activated Protein KinasesCatechinepigallocatechin gallateKEAP1 protein, ratKelch-Like ECH-Associated Protein 1Nfe2l2 protein, ratNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratSeleniumSirtuin 1AMPK/SIRT1/PGC-1α/MFN2 signalingEGCG-functionalized selenium nanoparticlesHFD-induced hepatic lipotoxicityKeap1/Nrf2 antioxidant axismitochondrial apoptosisNF-κB-mediated inflammation

Identifiers

PMID42450041
PMCPMC13362397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.