Evidence map›Paper›PMID 42450083›Full record

ArticleInternational journal of molecular sciences2026

Endothelial VEGFR-2 Activation Precedes Severe Mucosal Injury in TNBS-Induced Colitis.

Sabrina Ceccariglia, Diego Sibilia, Alice Scattolini, Valentina Saccone, Ornella Parolini, Alessandro Armuzzi, Alfredo Papa, Antonio Gasbarrini, Fabrizio Pizzolante

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sabrina CeccarigliaDepartment of Life Science and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Diego SibiliaDepartment of Life Science and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Alice ScattoliniDepartment of Life Science and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0009-0004-9989-8638
Valentina SacconeDepartment of Life Science and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Ornella ParoliniDepartment of Life Science and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-5211-6430
Alessandro ArmuzziIBD Center IRCSS, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Alfredo PapaCEMAD (Digestive Disease Center), Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-4186-7298
Antonio GasbarriniCEMAD (Digestive Disease Center), Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-6230-1779
Fabrizio PizzolanteCEMAD (Digestive Disease Center), Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-1863-8232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial VEGFR-2 plays a central role in vascular remodeling during intestinal inflammation, yet its activation during the early stages of colitis remains poorly characterized. Because Akt is a major downstream effector of VEGFR-2 signaling and a key mediator of endothelial responses, we investigated whether VEGFR-2 phosphorylation and Akt activation occur during the early phase of TNBS-induced colitis before the development of extensive mucosal injury. Acute colitis was induced in adult female Wistar rats by intracolonic administration of TNBS. Colonic tissues were collected on days 2, 4, and 6 after induction. Histological analyses and macrophage (CD68

Indexed as

ColitisIntestinal MucosaVascular Endothelial Growth Factor Receptor-2AnimalsAntigens, CDCD68 MoleculeColonDisease Models, AnimalFemaleMacrophagesPhosphorylationProto-Oncogene Proteins c-aktRatsRats, WistarSignal TransductionTrinitrobenzenesulfonic AcidAntigens, CDCD68 MoleculeProto-Oncogene Proteins c-aktTrinitrobenzenesulfonic AcidVascular Endothelial Growth Factor Receptor-2endothelial responseinflammatory bowel diseaseTNBS colitisVEGF-A expressionVEGFR-2 activation

Identifiers

PMID42450083
PMCPMC13360810

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.