ArticleInternational journal of molecular sciences2026
Vitamin D Receptor rs731236 Polymorphism Modulates Cancer Cachexia Susceptibility and Overall Survival: A Real-World Study on Context-Dependent Vitamin D Signalling.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Valéria TavaresMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0003-3680-7757
Ana Carolina Leão SilvaMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0002-1969-9363
Anna Flávia XavierMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0003-3072-4969
Inês Guerra de MeloMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.
Tiago FerreiraMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0002-6652-9770
Mariana Moreira PiresMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.
Cláudia SilvaDay Hospital, Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal.
Virgínia Rocha DiasDay Hospital, Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal.
Maria Paula SilvaPalliative Care Service, Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal.
Joana M O SantosMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0002-6268-524X
Rui MedeirosMolecular Oncology and Viral Pathology Group, IPO Porto Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Department of Pathology and Laboratory Medicine/RISE-Associate Laboratory (Health Research Network)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal.ORCID 0000-0003-3010-8373
Funding
and Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production LA/P/0126/2020Centre for the Research and Technology of Agro-Environmental and Biological Sciences UIDB/04033/2025IPO Porto PI127-CI-IPOP-118-2019Portuguese League Against Cancer - Northern Branch
6 · The paper itself
Abstract
Cancer-associated cachexia (CAC) is a complex metabolic syndrome characterised by progressive skeletal muscle loss, systemic inflammation, reduced treatment tolerance, and poor survival. Marked interindividual variability in CAC susceptibility suggests that host genetic factors may contribute to its development. Vitamin D plays an important role in muscle metabolism and inflammatory control through activation of the vitamin D receptor (VDR). VDR signalling influences myogenesis, mitochondrial function, insulin-like growth factor pathways, and pro-inflammatory cytokine expression, all of which are implicated in CAC pathogenesis. Hence,
Indexed as
CachexiaGenetic Predisposition to DiseaseNeoplasmsPolymorphism, Single NucleotideReceptors, CalcitriolVitamin DAdultAgedFemaleGenotypeHumansMaleMiddle AgedSignal TransductionReceptors, CalcitriolVDR protein, humanVitamin Dbiomarkerscachexianeoplasmspolymorphismsingle nucleotideVDR
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.