Oleuropein Attenuates 6-Hydroxydopamine-Induced Cytotoxicity Through Redox Regulation in Differentiated Dopaminergic Neurons: Potential Involvement of RET-Associated Signalling.

Bushra Y Ahmed, Sigrun Lange, Mohamad Warda, Azizeh Shadidizaji, Pinar Uysal-Onganer

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Bushra Y AhmedInstitute for Health & Wellbeing Research, University Square, University of Bedfordshire, Luton LU1 3JU, UK.ORCID 0009-0002-3634-3550

Sigrun LangePathobiology and Extracellular Vesicles Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK.ORCID 0000-0002-7193-3102

Mohamad WardaDepartment of Physiology, Faculty of Veterinary Medicine, Atatürk University, Erzurum 25240, Türkiye.ORCID 0000-0003-0516-4023

Azizeh ShadidizajiDepartment of Agricultural Biotechnology, Faculty of Agriculture, Ataturk University, Erzurum 25240, Türkiye.ORCID 0009-0007-5573-1360

Pinar Uysal-OnganerCancer Mechanisms and Biomarkers Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK.ORCID 0000-0003-3190-8831

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by selective loss of dopamine-containing neurons (DCNs) in the substantia nigra. Oxidative stress and impaired neurotrophic signalling contribute to PD pathogenesis. Oleuropein (Ole), a phenolic compound found in olives and olive leaves, exhibits antioxidant and cytoprotective properties that may counteract neuronal injury. This study investigated the neuroprotective effects of Ole in differentiated dopaminergic neurons (dDCNs) derived from the human ReNcell VM model exposed to 6-hydroxydopamine (6-OHDA). Ole significantly attenuated 6-OHDA-induced cytotoxicity, restoring cell viability following post- and pre-treatment compared with toxin-treated cells. Tyrosine hydroxylase expression was preserved, indicating maintenance of the dopaminergic phenotype. Ole also reduced lipid peroxidation and restored total antioxidant capacity, supporting a role in redox homeostasis. Molecular docking suggested a stable interaction between Ole and the RET receptor tyrosine kinase, suggesting a potential involvement of RET-associated survival signalling pathways that requires further experimental validation. In addition, 6-OHDA altered extracellular vesicle (EV) release and EV-associated transcripts related to

Indexed as

Dopaminergic NeuronsIridoidsNeuroprotective AgentsOxidopamineProto-Oncogene Proteins c-retCell DifferentiationCell SurvivalHumansIridoid GlucosidesMolecular Docking SimulationOxidation-ReductionOxidative StressSignal TransductionIridoid GlucosidesIridoidsNeuroprotective AgentsoleuropeinOxidopamineProto-Oncogene Proteins c-ret6-hydroxydopamineextracellular vesiclesoleuropeinParkinson’s diseaseRET signallingWnt signalling

Identifiers

PMID42450163

DOI10.3390/ijms27135892

PMCPMC13361532

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.