ArticleInternational journal of molecular sciences2026
Novel C3/C28-bis-1,2,4-Triazolyl-sulfanylacetate-betulin Derivatives: Synthesis and Evaluation of Anticancer Potential.
Alexandra Prodea, Marius Mioc, Andreea Munteanu, Alexandra Mioc, Nicoleta Anamaria Paşcalău, Bogdan-Ionuț Mara, Elisabeta Atyim, Mihaela Balan-Porcarasu, Roxana Racoviceanu, Codruța Șoica
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Alexandra ProdeaFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-7955-422X Marius MiocFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Andreea MunteanuFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-6588-3241 Alexandra MiocFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0001-6459-2074 Nicoleta Anamaria PaşcalăuDepartment of Psycho Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.ORCID 0000-0002-3113-7232 Bogdan-Ionuț MaraFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0009-0001-6907-1857 Elisabeta AtyimFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0009-0006-6128-3632 Roxana RacoviceanuFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-3378-0774 Codruța ȘoicaFaculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Funding
Romanian National Authority for Scientific Research PN-IV-P2-2.1-TE-2023-0717Victor Babeș University of Medicine and Pharmacy Timișoara
6 · The paper itselfAbstract
The current study describes the synthesis and preliminary anticancer assessment of a novel series of C3/C28-bis-1,2,4-triazolyl-sulfanylacetate-betulin (AP1-5) derivatives to identify potent agents for clinical development. The cytotoxicity of AP1-5 was evaluated using the Alamar blue assay against MCF-7, A375, PANC-1 (cancer cells) and HaCat (human keratinocytes) cells. Moreover, the molecular mechanisms responsible for cytotoxicity were investigated through in vitro (DCFDA/H
Indexed as
Antineoplastic AgentsTriazolesTriterpenesApoptosisBetulinic AcidCell Line, TumorHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationAntineoplastic AgentsbetulinBetulinic AcidTriazolesTriterpenesanticancerbetulinbistriazolemolecular dockingmolecular dynamics simulationnetwork pharmacologypentacyclic triterpenetriazole
Identifiers
PMID42450229
PMCPMC13361304
What Socratic holds
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LicenceCC BY
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