Evidence map›Paper›PMID 42450240›Full record

SynthesisInternational journal of molecular sciences2026

Interleukin-1β (C-511T) Genetic Variant and Major Depressive Disorder: A Systematic Review.

Bruna Rodrigues Gontijo, Caroline Ferreira Fratelli, Larissa Sousa Silva Bonasser, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Silva

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bruna Rodrigues GontijoPostgraduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 72220-900, Brazil.ORCID 0000-0001-6662-7138
Caroline Ferreira FratelliPostgraduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 72220-900, Brazil.ORCID 0000-0002-0511-9452
Larissa Sousa Silva BonasserPostgraduate Program in Health Sciences, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 70910-900, Brazil.ORCID 0000-0002-7812-8026
Calliandra Maria de Souza SilvaPostgraduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 72220-900, Brazil.ORCID 0000-0002-9064-0735
Izabel Cristina Rodrigues da SilvaPostgraduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 72220-900, Brazil.ORCID 0000-0002-6836-3583

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Foundation for Research Support of the Federal District SEI nº 00193-00002187/2023-24 - Notice 09/2023 - Spontaneous DemandNational Council for Scientific and Technological Development 444755/2023-3Universidade de Brasília UnB-DPG-DPI - 0022022
6 · The paper itself

Abstract

Major Depressive Disorder (MDD) has a multifactorial etiology and pathogenesis that significantly impacts an individual's quality of life. One of the possible correlations for its onset is the activation of inflammatory responses resulting in neurodegeneration and, consequently, the emergence of depressive symptoms. Interleukin-1β is a regulatory cytokine of the immune and nervous systems that acts on several processes, including mood regulation. This systematic review analyzed the

Indexed as

Genetic Predisposition to DiseaseInterleukin-1betaMajor Depressive DisorderPolymorphism, Single NucleotideAntidepressive AgentsGenotypeHumansAntidepressive AgentsInterleukin-1betaantidepressant responsebiomarkersC-511T polymorphism (rs16944)cytokines and inflammationgenetic variantinterleukin-1β (IL1β)major depressive disorder (MDD)neurodegenerationpersonalized medicinePsychiatric genetics

Identifiers

PMID42450240
PMCPMC13361593

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.